Our publications reflect Franklin Lab’s commitment to uncovering the molecular mechanisms that drive cardiac hypertrophy and heart failure and translating these discoveries toward better therapies. Our research integrates cardiac epigenetics, proteomics, and basic cardiovascular science to investigate how molecular and cellular processes shape cardiac function, remodeling, and disease progression. From defining novel epigenetic mechanisms to identifying proteomic signatures and therapeutic targets, our work advances fundamental understanding of the diseased heart while opening new avenues for the prevention and treatment of heart failure and other cardiovascular diseases.
Cardiomyocyte-specific loss of Smyd5 leads to a robust activation of inflammatory signaling and heart failure in mice.
Bia R., Hickenlooper S M, Miller M R, Li C C, Horiuchi E, Bakhtina A, Wang L, Valdez S, Davis K, Anderson A, Garcia-Llana J, Farese L, O’Very S, Santa Ana N, Jacobsen A, Dellerman K, Gwynn C, Durrant J, Visker J R, Kyriakopoulos C P, Sideris K, Drakos S G, Szulik M W, Thorp E B, Smale S T, Franklin S.
bioRxiv link coming soon
Smyd1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.
Szulik M W, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O’Very S, Laxman A K, Sandaklie-Nicolova L, Eberhardt D R, Durrant J R, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos S G, Funai K, Chaudhuri D, Boudina S, Franklin S.
Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support.
Drakos S G, Badolia R, Makaju A, Kyriakopoulos C P, Wever-Pinzon O, Tracy C M, Bakhtina A, Bia R, Parnell T, Taleb I, Ramadurai D K A, Navankasattusas S, Dranow E, Hanff T C, Tseliou E, Shankar T S, Visker J, Hamouche R, Stauder E L, Caine W T, Alharethi R, Selzman C H, Franklin S.